{"id":4658,"date":"2023-11-03T17:30:41","date_gmt":"2023-11-03T09:30:41","guid":{"rendered":"https:\/\/aict.nkust.edu.tw\/digitrans\/?p=4658"},"modified":"2023-11-03T17:30:43","modified_gmt":"2023-11-03T09:30:43","slug":"deepmind%e7%99%bc%e5%b8%83%e6%96%b0%e7%89%88alphafold%e6%a8%a1%e5%9e%8b%ef%bc%8c%e8%83%bd%e5%a4%a0%e7%b2%be%e6%ba%96%e9%a0%90%e6%b8%ac%e7%94%9f%e7%89%a9%e5%88%86%e5%ad%90%e7%b5%90%e6%a7%8b%e5%8a%a0","status":"publish","type":"post","link":"https:\/\/aict.nkust.edu.tw\/digitrans\/?p=4658","title":{"rendered":"DeepMind\u767c\u5e03\u65b0\u7248AlphaFold\u6a21\u578b\uff0c\u80fd\u5920\u7cbe\u6e96\u9810\u6e2c\u751f\u7269\u5206\u5b50\u7d50\u69cb\u52a0\u901f\u85e5\u7269\u958b\u767c"},"content":{"rendered":"\n

\u674e\u5efa\u8208 | 2023-11-03<\/p>\n\n\n\n

Google DeepMind\u8207Isomorphic Labs\u6301\u7e8c\u5408\u4f5c\u767c\u5c55\u86cb\u767d\u8cea\u9810\u6e2c\u6a21\u578bAlphaFold\uff0c\u73fe\u5728\u958b\u767c\u51fa\u66f4\u5f37\u5927\u7684\u65b0\u7248\u672c<\/a>\uff0c\u8986\u84cb\u7bc4\u570d\u5f9e\u86cb\u767d\u8cea\u64f4\u5c55\u5230\u6240\u6709\u8207\u751f\u7269\u76f8\u95dc\u7684\u5206\u5b50\uff0c\u4e26\u80fd\u5920\u5c0d\u86cb\u767d\u8cea\u8cc7\u6599\u5eab\u4e2d\u5e7e\u4e4e\u6240\u6709\u5206\u5b50\u9032\u884c\u9810\u6e2c\uff0c\u4e14\u80fd\u9054\u5230\u539f\u5b50\u7b49\u7d1a\u7684\u7cbe\u78ba\u5ea6\u3002<\/p>\n\n\n\n

DeepMind\u57282020\u5e74\u7684\u6642\u5019\uff0c\u9996\u6b21\u63a8\u51fa\u86cb\u767d\u8cea\u9810\u6e2c\u6a21\u578bAlphaFold\uff0c\u800c\u9019\u8b93\u7814\u7a76\u4eba\u54e1\u80fd\u4ee5\u5168\u65b0\u65b9\u5f0f\u7406\u89e3\u86cb\u767d\u8cea\u8207\u5176\u4ea4\u4e92\u4f5c\u7528\u3002AlphaFold\u662f\u5c0d\u55ae\u80a1\u86cb\u767d\u8cea\u9810\u6e2c\u7684\u7a81\u7834\u6027\u7814\u7a76\uff0c\u800c\u5f8c\u7684AlphaFold-Multimer\uff0c\u5247\u662f\u9032\u4e00\u6b65\u64f4\u5c55\u5230\u64c1\u6709\u591a\u500b\u86cb\u767d\u8cea\u93c8\u7684\u8907\u5408\u7269\uff0c\u800cAlphaFold 2.3\u5247\u64f4\u5c55\u5230\u66f4\u8907\u96dc\u7684\u8907\u5408\u7269\u3002<\/p>\n\n\n\n

\u4e4b\u524dAlphaFold\u4e5f\u8207EMBL\u7684\u6b50\u6d32\u751f\u7269\u8cc7\u8a0a\u7814\u7a76\u6240\uff08EMBL-EBI\uff09\u5408\u4f5c\uff0c\u900f\u904eAlphaFold\u86cb\u767d\u8cea\u7d50\u69cb\u8cc7\u6599\u5eab\uff0c\u516c\u958b\u6240\u6709\u76ee\u524d\u5df2\u77e5\u7684\u86cb\u767d\u8cea\u7d50\u69cb\u9810\u6e2c\u3002\u800cAlphaFold\u8cc7\u6599\u5eab\u4e5f\u5df2\u7d93\u6210\u70ba\u91cd\u8981\u7684\u79d1\u5b78\u7814\u7a76\u8cc7\u6e90\uff0c\u5230\u76ee\u524d\u70ba\u6b62\u5df2\u7d93\u8d85\u904e190\u500b\u570b\u5bb6140\u842c\u7528\u6236\u9032\u884c\u5b58\u53d6\uff0c\u540c\u6642AlphaFold\u4e5f\u88ab\u7528\u65bc\u52a0\u901f\u65b0\u578b\u75ab\u82d7\u548c\u85e5\u7269\u7684\u958b\u767c\u3002<\/p>\n\n\n\n

\u5728\u67d0\u4e9b\u8207\u85e5\u7269\u958b\u767c\u76f8\u95dc\u7684\u86cb\u767d\u8cea\u7d50\u69cb\u9810\u6e2c\u554f\u984c\uff0c\u6700\u65b0\u7248\u672c\u7684AlphaFold\u6548\u80fd\u9060\u52dd2.3\u7248\u672c\uff0c\u5176\u80fd\u5920\u6e96\u78ba\u9810\u6e2c\u86cb\u767d\u8cea\u8207\u914d\u9ad4\uff08Ligand\uff09\u7684\u7d81\u5b9a\u7d50\u69cb\uff0c\u7814\u7a76\u4eba\u54e1\u6307\u51fa\uff0c\u9019\u5c0d\u65bc\u85e5\u7269\u958b\u767c\u975e\u5e38\u6709\u50f9\u503c\u3002\u76ee\u524d\u751f\u91ab\u7522\u696d\u4e3b\u8981\u4f7f\u7528\u5c0d\u63a5\u65b9\u6cd5\uff08Docking Methods\uff09\uff0c\u4f86\u78ba\u5b9a\u914d\u9ad4\u548c\u86cb\u767d\u8cea\u9593\u7684\u4ea4\u4e92\u4f5c\u7528\uff0c\u4f46\u9019\u985e\u65b9\u6cd5\u9700\u8981\u56fa\u5b9a\u53c3\u8003\u86cb\u767d\u8cea\u7d50\u69cb\uff0c\u548c\u914d\u9ad4\u7d81\u5b9a\u4f4d\u7f6e\u3002<\/p>\n\n\n\n

\u4e0d\u904e\uff0c\u65b0\u6a21\u578b\u537b\u4e0d\u9700\u8981\u9019\u4e9b\u53c3\u8003\u8cc7\u8a0a\uff0c\u5c31\u80fd\u9810\u6e2c\u86cb\u767d\u8cea\u8207\u914d\u9ad4\u7684\u7d50\u69cb\uff0c\u4e26\u4e14\u6700\u7d42\u7684\u7d50\u679c\u4e5f\u80fd\u8d85\u8d8a\u76ee\u524d\u6700\u4f73\u7684\u5c0d\u63a5\u65b9\u6cd5\uff0c\u6b64\u5916\uff0c\u65b0\u7248\u672cAlphaFold\u9084\u53ef\u4ee5\u6a21\u64ec\u6240\u6709\u539f\u5b50\u7684\u4f4d\u7f6e\uff0c\u8868\u9054\u51fa\u86cb\u767d\u8cea\u548c\u6838\u9178\uff0c\u5728\u8207\u5176\u4ed6\u5206\u5b50\u4ea4\u4e92\u4f5c\u7528\u6642\u7684\u9748\u6d3b\u6027\u3002<\/p>\n\n\n\n

\u7531\u65bc\u5c0d\u63a5\u65b9\u6cd5\u9700\u8981\u5047\u8a2d\u86cb\u767d\u8cea\u548c\u914d\u9ad4\u7d50\u69cb\u5728\u4ea4\u4e92\u6642\u7dad\u6301\u4e0d\u8b8a\uff0c\u56e0\u6b64\u5c31\u7121\u6cd5\u6355\u6349\u5230\u9019\u4e9b\u7d50\u69cb\u7684\u52d5\u614b\u8b8a\u5316\uff0c\u56e0\u6b64\u6574\u9ad4\u4f86\u8aaa\uff0c\u65b0\u6a21\u578b\u80fd\u5920\u63d0\u4f9b\u66f4\u70ba\u6e96\u78ba\u4e14\u5168\u9762\u7684\u4ea4\u4e92\u4f5c\u7528\u7d50\u69cb\u8cc7\u8a0a\u3002\u7814\u7a76\u4eba\u54e1\u7684\u5be6\u9a57\u4e5f\u8b49\u660e\uff0c\u65b0\u6a21\u578b\u9810\u6e2c\u7684\u7d50\u69cb\uff0c\u8207\u5be6\u9a57\u6240\u5f97\u5230\u7d50\u69cb\u975e\u5e38\u76f8\u8fd1\u3002<\/p>\n\n\n\n

\u76ee\u524dIsomorphic Labs\u6b63\u5728\u5229\u7528\u6700\u65b0\u7684AlphaFold\u8a2d\u8a08\u6cbb\u7642\u6027\u85e5\u7269\uff0c\u85c9\u7531\u904b\u7528AlphaFold\u5feb\u901f\u4e14\u6e96\u78ba\u5730\u63cf\u7e6a\u51fa\u5c0d\u6cbb\u7642\u75be\u75c5\u91cd\u8981\u7684\u5927\u5206\u5b50\u7d50\u69cb\u3002\u7814\u7a76\u4eba\u54e1\u63d0\u5230\uff0c\u8a72\u6a21\u578b\u65b0\u589e\u7684\u529f\u80fd\uff0c\u6709\u52a9\u65bc\u52a0\u901f\u751f\u7269\u91ab\u5b78\u7684\u7a81\u7834\uff0c\u5728\u75be\u75c5\u9014\u5f91\uff08Disease Pathways\uff09\u3001\u57fa\u56e0\u9ad4\u5b78\u3001\u751f\u7269\u53ef\u518d\u751f\u6750\u6599\u548c\u85e5\u7269\u8a2d\u8a08\u6a5f\u5236\u7b49\u9818\u57df\uff0c\u63d0\u4f9b\u66f4\u6df1\u5165\u7684\u7406\u89e3\u3002<\/p>\n\n\n\n

\u8cc7\u6599\u4f86\u6e90\uff1ahttps:\/\/www.ithome.com.tw\/news\/159612<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u674e\u5efa\u8208 | 2023-11-03 Google DeepMind\u8207Isomorphic Labs\u6301\u7e8c\u5408\u4f5c\u767c\u5c55\u86cb\u767d\u8cea\u9810\u6e2c\u6a21\u578bAlphaFold\uff0c\u73fe\u5728\u958b\u767c\u51fa\u66f4\u5f37\u5927\u7684\u65b0\u7248\u672c\uff0c\u8986\u84cb\u7bc4\u570d\u5f9e\u86cb…<\/p>\n","protected":false},"author":9,"featured_media":4659,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[4],"tags":[26,40],"class_list":["post-4658","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news","tag-ai","tag-40"],"gutentor_comment":0,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/aict.nkust.edu.tw\/digitrans\/wp-content\/uploads\/2023\/11\/a_glimpse_of_the_next_generation_of_alphafold_-_google_deepmind_-_deepmind.google-e1699003830792.png?fit=561%2C420&ssl=1","jetpack-related-posts":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=\/wp\/v2\/posts\/4658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4658"}],"version-history":[{"count":1,"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=\/wp\/v2\/posts\/4658\/revisions"}],"predecessor-version":[{"id":4660,"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=\/wp\/v2\/posts\/4658\/revisions\/4660"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=\/wp\/v2\/media\/4659"}],"wp:attachment":[{"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/aict.nkust.edu.tw\/digitrans\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}